Laboratory of Regulation of Gene Expression
Head of the Laboratory:
Dr. rer. nat. Leoš Shivaya Valášek, DSc.
Phone: +420 241 062 288
E-mail: valasekl@biomed.cas.cz
| Dr. rer. nat. Leoš Valášek, DSc. | Head of the Laboratory |
| RNDr. Stanislava Gunišová, Ph.D | Scientist |
| RNDr. Anna Herrmannová, Ph.D. | Postdoctoral fellow |
| Mgr. Petra Beznosková, Ph.D | Postdoctoral fellow |
| MSc. Mohammad Mahabub Pasha | Postdoctoral fellow |
| RNDr. Adriana Roithová, Ph.D. | Postdoctoral fellow |
| Mgr. Terezie Prilepskaja | PhD student |
| Msc. Anna Michajlovna Smirnova | PhD student |
| Mgr. Kristýna Jendruchová | PhD student |
| Ing. Zuzana Pavlíková | PhD student |
| Mgr. Klára Pospíšilová | PhD student |
| Olga Staňková | Technician |
| Petra Miletínová | Research assistant |
Our Laboratory of regulation of gene expression was established in June 2006 and investigates basics of one of the fundamental molecular processes in the cell; i.e. protein synthesis and its regulation at both general as well as gene-specific level. Simply speaking, our mostly basic research is focused on figuring out how the cell deciphers the genetic code of DNA using a relatively simple decoding key and makes use of this gene-encoded information to make specific proteins – cell effectors – through very complex and delicate process called translation. In addition, we are interested in understanding how this process is regulated in response to constantly changing environmental conditions that the cell is facing and has to promptly react to in order to adapt its repertoire of proteins that it currently produces. With respect to the importance of our research from the social and medical (human health) point of view, we wish to broaden and deepen general awareness about how these fundamental cellular processes properly operate in the cell, so that our colleagues who are interested mainly in applied research; i.e. research directly focused on development of the most appropriate treatment of a particular decease, can feed from it while investigating the pathology of their deceases of interest and a potential “fixing” cure with drugs etc. Our studies combine the use of the budding yeast Saccharomyces cerevisiae model organism and mammalian cells lines and employ tools of molecular and structural biology, biochemistry and genetics. Our research is supported by the world renowned funding bodies such as the the Wellcome Trust, Howard Hughes Medical Institute a NIH FIC. By no means we can forget to mention also a financial support of the Czech grant agency, for example in a form of the prestigious Center of Excellence grant awarded to us in 2010. We are a small group (~10 people) of keen, honest, passionate and hard-working researchers from post-docs to bachelor students with one very skillful lab assistant, who are eager to learn more and more every day and have fun at the same time.
translation initiation factor 3 (eIF3) on the small (40S) ribosomal subunit
translation initiation factor 3 (eIF3) in the Multifactor complex