Laboratory of Infection Biology
Head of the Laboratory:
RNDr. Jana Kamanová, PhD.
Tel.: +420 241 062 018
|RNDr. Jana Kamanová, PhD.||Head of the Laboratory|
|RNDr. Ivana Malcová, CSc.||Scientist|
|RNDr. Ondřej Černý, PhD.||Postdoctoral fellow|
|Ing. Hana Michová, PhD.||Postdoctoral fellow|
|Ing. Martin Zmuda||PhD student|
|Mgr. Milada Kambová||PhD student|
|Msc. Alona Dreus||PhD student|
|Msc. Tania Romero Allsop||Research assistant|
|Msc. Darío Martín||Research assistant|
|RNDr. Dana Janošková||Research assistant|
|Mgr. Barbora Pravdová||Research assistant|
|Bc. Anežka Jirsová||Master student|
|Bc. Paulína Mathéová||Master student|
|Bc. Eliška Sedláčková||Master student|
|Bc. Denisa Vondrová||Master student|
Our laboratory focuses on understanding how bacteria cause disease. The research addresses molecular and cellular mechanisms that underlay bacterial virulence with special emphasis on type III effector proteins. The type III effector proteins are injected into the host cell by a bacterial syringe-like apparatus, known as a type III secretion system, in order to manipulate host cell signaling pathways and defense. We unravel how type III effector proteins act inside host cells and what are the details and functional consequences of their interactions and/or enzymatic activities.
Our model system are pathogenic Bordetella species that colonize the respiratory tract of mammals and cause respiratory infections. We aim to understand the molecular mechanism of action of BteA effector and its role in the pathogenesis of whooping cough disease caused by B. pertussis and B. parapertussis.
We also target the genus of aquatic Aeromonas. These bacteria encode various type III secretion effectors with yet undiscovered functions. We decode their role in the symbiosis of Aeromonas with the medicinal leech.
More information: www.kamanova-lab.com