Laboratory of Molecular Biology of Bacterial Pathogens

Head of the Laboratory:
prof. Ing. Peter Sebo, CSc.

Cell Phone: +420 774 798 121 (business)
Phone:         +420 24106 2762 (secretary and voice mail)
Fax:              +420 241 062 152

prof. Ing. Peter Šebo, CSc. Head of the Laboratory
Ing. Radim Osička, Ph.D. Scientist
Mgr. Ladislav Bumba, Ph.D. Scientist
RNDr. Jiří Mašín, Ph.D. Scientist
RNDr. Jana Holubová, Ph.D. Associated scientist
Ing. Adriana Osičková Ph.D. Associated scientist
RNDr. Irena Linhartová, CSc. Associated scientist
Ing. Ondřej Staněk, Ph.D. Associated scientist
Mgr. Eva Slivenecká, Ph.D. Associated scientist
Mgr. David Jurnečka, Ph.D. Postdoctoral fellow
Mgr. Jawid Nazir Ahmad, Ph.D. Postdoctoral fellow
Dr. Maryam Goldshani, Ph.D. Postdoctoral fellow
Mgr. Ludmila Brázdilová PhD student
Mgr. Nela Klímová PhD student
Waheed Ur Rahman, MSc. PhD student
Carlos Angel Espinosa Vinals, MSc. PhD student
Humaira Khaliq Research assistant
MUDr. Šárka Knoblochová Research assistant
Anna Lepesheva Research assistant
Ing. Kateřina Filipi Research assistant
Hana Lukeová Technician
Soňa Kozubová Technician
Iva Maršíková Technician
Attila Juhász Technician
Michaela Grobarčíková Technician
Karyna Zhuk Technician
Ilona Krupičková Sekretářka

We study tricks and tools used by pathogenic bacteria to suppress our immune defense. In particular, we study the whooping cough agent Bordetella pertussis that causes the respiratory illness called pertussis. This infectious disease can be fatal to smallest non-vaccinated infants and is currently on the rise in the most developed and wealthiest countries (where vaccine refusal is on the rise and less reactogenic but also less efficacious pertussis vaccines are used).

The major focus of our research is on the structure and mechanisms of action of the adenylate cyclase toxin (ACT). This major virulence factor plays a crucial role in suppression of the sentinel functions of host phagocytes in the course of infection. Thereby it enables bacteria to colonize the airway epithelia of the host. We are analyzing the mechanisms underlying toxin penetration into phagocytes and the mechanisms by which its action paralyzes cellular signaling and killing of bacteria. One of our projects aims at development of a next generation of pertussis vaccines. Besides basic research on “how” does the toxin work we are also co-authors of international patents on the use of detoxified forms of ACT in vaccines. We contributed to development of an immunological technology that is currently under clinical evaluation for immunotherapy of cervical tumors in ladies infected by human papillomavirus.

Our credo is “knowledge is useful”. Through highest quality basic research we strive for gaining of deepest understanding of “HOW IT WORKS”. At the same time we search for ways how to use the acquired knowledge for the benefit of the taxpayer that funds our scientific work.

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